Non-Hodgkin’s Lymphoma Diagnosed in the Puerperium: A Case Report

A 28-year-old primigravida presented in the third trimester with a sore throat and cervical swelling. She was initially treated for an upper respiratory tract infection. At 41 weeks, she delivered vaginally due to oligohydramnios. Her symptoms progressed during the puerperium, and imaging revealed cervical lymphadenopathy. Biopsy confirmed diffuse large B-cell lymphoma (non-germinal center phenotype). Chemotherapy was initiated, and clinical follow-up is ongoing. Immunologic changes during pregnancy may increase susceptibility to lymphoproliferative disorders, particularly Hodgkin lymphoma. However, the diagnosis of non-Hodgkin lymphoma (NHL) during pregnancy or the postpartum period is exceedingly rare and often delayed. Case reports remain valuable in increasing clinical vigilance and improving early detection. A comprehensive systemic evaluation is warranted in pregnant or postpartum patients presenting with persistent lymphadenopathy. Lymphoma should be considered in the differential diagnosis of cervical and submandibular masses during this period. Early recognition and treatment of NHL in pregnancy can significantly reduce maternal morbidity and mortality.