E-ISSN: 2148-4570 • ISSN:2148-4570
Evaluation Of The Relationship Between High-Density Lipoprotein Cholesterol Levels And Community-Acquired Pneumonia Severity In Adult Patients [Ankara Med J]
Ankara Med J. 2022; 22(1): 118-128 | DOI: 10.5505/amj.2022.98957

Evaluation Of The Relationship Between High-Density Lipoprotein Cholesterol Levels And Community-Acquired Pneumonia Severity In Adult Patients

Habibe Hezer1, Ebru Sengul Parlak1, Afra Alkan2, Hatice Canan Hasanoglu3, Emine Argüder3, Berker Öztürk4, Aysegul Karalezli3
1Ankara City Hospital, Clinical of Pulmonary Diseases, Ankara, Turkey
2Yıldırım Beyazıt University, Faculty of Medicine, Department of Biostatistics, Ankara, Turkey
3Yıldırım Beyazıt University Faculty of Medicine, Department of Pulmonary Diseases, Ankara, Turkey
4Aksaray Training and Research Hospital, Clinical of Pulmonary Diseases, Aksaray, Turkey

INTRODUCTION: Inflammation and acute phase reactions lead to altered high-density lipoprotein cholesterol (HDL-C) concentrations. This study aimed to evaluate HDL-C levels in community-acquired pneumonia (CAP) and to determine the predictive value of disease severity in CAP.
METHODS: In this prospective cross sectional study was conducted in the Department of Pulmonary Diseases. One hundred twenty-five adult patients with CAP were included in the study. Patients were classified into three groups as follows: Group 1; outpatients, Group 2; hospitalized patients and Group 3; patients admitted to the intensive care unit. C-reactive protein (CRP), procalcitonin (PCT) and HDL-C levels were evaluated at baseline, 7th and 30th days in all CAP patients. The relationship between CRP, PCT and HDL-C levels was investigated. Diagnostic performance of baseline HDL-C levels was assessed using receiver-operating characteristic (ROC) curve analyses.
RESULTS: HDL-C levels were found to be decreased in all groups compared to their normal ranges. There was a significantly negative correlation between HDL-C and CRP and PCT (Spearman’s r= -0.557, r= -0.841, respectively; p< 0.001). The sensitivity and specificity of HDL-C cut-off value were 0.738 (95% CI: 0.580-0.861) and 0.875 (95% CI: 0.732-0.958), with an overall accuracy of 0.861 (95% CI: 0.728-0.935).
DISCUSSION AND CONCLUSION: HDL-C levels can be used as an acute phase reactant in patients with CAP.

Keywords: Community-acquired pneumonia, high-density lipoprotein cholesterol, biomarker

Habibe Hezer, Ebru Sengul Parlak, Afra Alkan, Hatice Canan Hasanoglu, Emine Argüder, Berker Öztürk, Aysegul Karalezli. Evaluation Of The Relationship Between High-Density Lipoprotein Cholesterol Levels And Community-Acquired Pneumonia Severity In Adult Patients. Ankara Med J. 2022; 22(1): 118-128

Corresponding Author: Habibe Hezer, Türkiye
Manuscript Language: English
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