E-ISSN: 2148-4570 • ISSN:2148-4570
Ankara Medical Journal Evaluation of Large Unstained Cells (LUC) and Nitric Oxide in Diabetes Mellitus [Ankara Med J]
Ankara Med J. 2022; 22(4): 533-541 | DOI: 10.5505/amj.2022.65707

Evaluation of Large Unstained Cells (LUC) and Nitric Oxide in Diabetes Mellitus

Funda Eren1, Arzu Kösem2, Esra Fırat Oğuz1, Salim Neselioglu3, İhsan Ateş4, Ozcan Erel3
1Ankara City Hospital. Department of Medical Biochemistry Laboratory, Ankara, Turkey
2Ankara Dışkapı Research And Training Hospital, Department of Medical Biochemistry Laboratory Ankara, Turkey
3Yıldırım Beyazıt University, Department of Medical Biochemistry, Ankara, Turkey
4Ankara City Hospital. Clinic of Internal Medicine, Ankara, Turkey

INTRODUCTION: The large unstained cells (LUC) is a differential count parameter measured by routine hematology analyzers and reflects activated lymphocytes and peroxidase-negative cells in leukocytes. Nitric oxide (NO) is produced in all tissues in enzymatic and non-enzymatic ways. This study aimed to determine the levels of LUC and NO products (nitrite and nitrate) and to evaluate the LUC/NO ratio in patients with Diabetes Mellitus (DM).
METHODS: The study included 103 DM patients and 84 healthy controls. HbA1c, LUC/%LUC and total NO levels were measured. All the statistical calculations were performed using the Statistical Package for Social Sciences (SPSS) software program.
RESULTS: Nitric oxide levels of the patients were statistically significantly lower compared with the control group (p=0.004). LUC levels, LUC% values, LUC/NO, and LUC%/NO ratios were significantly higher in the DM group (p=0.002, p=0.009, p= <0.001, and p= <0.001, respectively). Statistically significant correlations were observed between HbA1c and nitrite, nitrate, NO, LUC/NO ratio, and LUC % /NO ratio.
DISCUSSION AND CONCLUSION: In this study, we determined the LUC/NO percent ratio and LUC%/NO percent ratio for the first time, according to our knowledge. We predict that these two parameters may be useful markers in the diagnosis and the follow-up of the disease and may provide target pathways for further studies that may contribute to the etiopathogenesis of the disease.

Keywords: Diabetes Mellitus, inflammation, LUC, NO.

Funda Eren, Arzu Kösem, Esra Fırat Oğuz, Salim Neselioglu, İhsan Ateş, Ozcan Erel. Evaluation of Large Unstained Cells (LUC) and Nitric Oxide in Diabetes Mellitus. Ankara Med J. 2022; 22(4): 533-541

Corresponding Author: Funda Eren, Türkiye
Manuscript Language: English
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