E-ISSN: 2148-4570 • ISSN:2148-4570
Ankara Medical Journal The Relationship of Neutrophil and Platelet Markers with Clinical Variables and Disease Activity in Patients with Ankylosing Spondylitis [Ankara Med J]
Ankara Med J. 2022; 22(4): 542-555 | DOI: 10.5505/amj.2022.11129

The Relationship of Neutrophil and Platelet Markers with Clinical Variables and Disease Activity in Patients with Ankylosing Spondylitis

Ender Erden1, Ayla Cagliyan Turk1, Ebru Erden1, İlker Fatih Sarı2
1Hitit University, Faculty Of Medicine, Department Of Physical Medicine And Rehabilitation, Corum, Turkey.
2Giresun University, Faculty Of Medicine, Department Of Physical Medicine And Rehabilitation, Giresun, Turkey

INTRODUCTION: The aim of this study is to show the relationship between neutrophil and platelet levels and clinical criteria such as disease activity and pain in ankylosing spondylitis (AS) patients.
METHODS: The study included 48 AS patients (Group 1) and 47 healthy controls (Group 2). Clinical and laboratory evaluations, including the measurement of the hemogram, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were performed. The AS patients were divided into two subgroups according to their disease activity was evaluated by using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score (≥4 high activity, <4 low activity).
RESULTS: Mean age of the patients was 42.44 ±12.32 years in Group 1 and 46.30 ± 9.10 years in Group 2 and showed no significant difference between groups (All p values >0.05). The ESR, CRP, NLR, PLR, and plateletcrit (PCT) values were significantly higher in Group 1, while the hemoglobin values were significantly lower in Group 2 (All p values <0.05). The platelet count was significantly higher in the subgroup with high disease activity according to the BASDAI score (All p values <0.05). A significantly negative weak correlation was found between MPV and BASMI and MPV and ESR (r=-0.303, p=0.037; r=-0.492, p<0.001, respectively). According to the receiver operating characteristic (ROC) analysis, PLR and MPV had diagnostic value in demonstrating disease activity.
DISCUSSION AND CONCLUSION: While NLR, PLR, and PCT can be used in the initial evaluation of inflammation in AS patients, PLR and MPV were found effective in demonstrating disease activity.

Keywords: Ankylosing spondylitis, mean platelet volume, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, plateletcrit.

Ender Erden, Ayla Cagliyan Turk, Ebru Erden, İlker Fatih Sarı. The Relationship of Neutrophil and Platelet Markers with Clinical Variables and Disease Activity in Patients with Ankylosing Spondylitis. Ankara Med J. 2022; 22(4): 542-555

Corresponding Author: Ebru Erden, Türkiye
Manuscript Language: English
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