E-ISSN: 2148-4570 • ISSN:2148-4570
Ankara Medical Journal The Effects of VDR Gene Polymorphisms and Lifestyle Features on Vitamin D Levels of Post Menopausal Women [Ankara Med J]
Ankara Med J. 2023; 23(3): 284-294 | DOI: 10.5505/amj.2023.03604

The Effects of VDR Gene Polymorphisms and Lifestyle Features on Vitamin D Levels of Post Menopausal Women

Meryem Çakır1, Esra Meltem Koç1, Mustafa Soyöz2, Hatice İlayhan Karahan Çöven2, Serpil Aydogmus3, Kaan Sozmen4
1Department Of Family Medicine, Izmir Katip Celebi University Atatürk Training And Research Hospital, Izmir, Turkey
2Department Of Medical Biology And Genetics, Izmir Katip Celebi University, Izmir, Turkey
3Department Of Gynecology And Obstetrics, Izmir Katip Celebi University Atatürk Training And Research Hospital, Izmir, Turkey
4Department Of Public Health, Izmir Katip Celebi University, Izmir, Turkey

INTRODUCTION: Vitamin D deficiency is a common situation for women who are in menopause due to various reasons. This study aims to investigate the effect of VDR gene polymorphisms and lifestyle on vitamin D levels of women in menopause.
METHODS: The study was planned in a cross-sectional descriptive design. Data was collected with a sociodemographic and lifestyle habits question form, and patients' blood samples were obtained for vitamin D levels and genetic tests. The data was evaluated by using SPSS 16.0 software. The logistic regression analysis model was created using the Backward elimination method, and the P-value below 0.05 was considered statistically significant.
RESULTS: The study was carried out on 303 menopausal women. The frequency of vitamin D deficiency in patients was 71.9%. Receiving vitamin D and Omega-3 supplements and having prolonged sleep duration were found to be protective factors from vitamin D deficiency. Of the VDR gene polymorphisms, the Bsml bb genotype was found to protect from vitamin D insufficiency, while the ApaI bb genotype increased the risk of vitamin D insufficiency.
DISCUSSION AND CONCLUSION: Vitamin D levels may be low in people who do not have sufficient sleep time. Our study found that the APA I aa genotype increased the risk of vitamin D deficiency, while the BsmI bb genotype protected from vitamin D deficiency. More studies are needed on the effects of lifestyle habits and genetic factors on serum vitamin D levels.

Keywords: Lifestyle, menopause, polymorphism, vitamin D

Meryem Çakır, Esra Meltem Koç, Mustafa Soyöz, Hatice İlayhan Karahan Çöven, Serpil Aydogmus, Kaan Sozmen. The Effects of VDR Gene Polymorphisms and Lifestyle Features on Vitamin D Levels of Post Menopausal Women. Ankara Med J. 2023; 23(3): 284-294

Corresponding Author: Meryem Çakır, Türkiye
Manuscript Language: English
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