A 26-year-old female patient presented to the family medicine outpatient clinic with complaints of diarrhea, widespread abdominal pain, nausea, and vomiting, which had been going on for five days. In the first physical examination findings of the patient, there was widespread sensitivity in the abdomen, but there were no findings of defense or rebound. The patient was re-evaluated with the results of conducted tests, her abdominal examination was repeated, and rebound positivity was detected in the right lower quadrant. The patient was referred to the Emergency Department, and she was taken into operation by the general surgery team with the diagnosis of acute appendicitis. The most important factor in delaying the diagnosis of acute appendicitis is the presence of gastroenteritis. Cases of acute appendicitis presenting with diarrhea have been reported in the medical literature. Since acute pathologies should always be kept in mind in the differential diagnosis of patients who present to primary care with abdominal pain and diarrhea, it is deemed appropriate to present the case with literature.Keywords: Appendicitis, enteritis, diarrhea, abdominal pain, abdomen, acute, appendix.