Ankara Med J. 2020; 20(1): 47-56 | DOI: 10.5505/amj.2020.71542

Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication

Fatih Tanrýverdi¹, Yucel Yuzbasioglu², Fadime Güllü Ercan Haydar³, Servan Gökhan¹, Ayhan Özhasenekler¹, Çaðdaþ Yýldýrým¹, Fatih Ahmet Kahraman¹, Funda Eren^4
1Department of Emergency Medicine, School of Medicine, Ankara Yýldýrým Beyazýt University, Ankara
²Department of Emergency Medicine, Keçiören Training and Research Hospital, Ankara
³Department of General Surgery, Ankara City Hospital, Ankara
⁴Department of Biochemistry, Ankara City Hospital, Ankara

INTRODUCTION: The aim of this study is to search if using thiol/disulphide homeostasis together with Neutrophile Lymphocyte Ratio (NLR) which are oxidative stress markers in patients who apply to the emergency service with carbon monoxide intoxication is useful regarding diagnosis or not.
METHODS: The study was performed prospectively with 45 patients who applied to the emergency service between 01.01.2014 - 01.03.2015 and who were included in the study and 40 healthy persons who were determined as control group. Thiol/disulphide homeostasis parameters (Thiol, disulphide, disulphide / native thiol, disulphide / total thiol, native thiol / total thiol) and NLR which are oxidative stress markers were studied in the patient and control groups by a method which was developed newly by Erel and Neþelioðlu.
RESULTS: In persons with carbon monoxide intoxication, a significant difference was detected in NT, TT, index 3 and NLR rates according to the control group. NT, TT and index 3 were found lower in the patient group, and NLR mean values were found higher in the patient group (p =0.005, < 0.001, = 0.032, < 0.001 respectively).
DISCUSSION AND CONCLUSION: To use NLR together with thiol/disulphide homeostasis parameters in the diagnosis of carbon monoxide intoxication is useful regarding diagnosing in these patients.

Keywords: Carbon monoxide intoxication, NLR, thiol/disulphide homeostasis.

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Karbonmonoksit Zehirlenmesinde Thiol Disulfid Homeostazisi ve Nötrofil Lenfosit Oraný Deðerlendirilmesi

Fatih Tanrýverdi¹, Yucel Yuzbasioglu², Fadime Güllü Ercan Haydar³, Servan Gökhan¹, Ayhan Özhasenekler¹, Çaðdaþ Yýldýrým¹, Fatih Ahmet Kahraman¹, Funda Eren^4
1Ankara Yýldýrým Beyazýt Üniversitesi Týp Fakültesi Acil Týp Anabilim Dalý,Ankara
²Keçiören Eðitim Araþtýrma Hastanesi Acil Týp Kliniði,Ankara
³Ankara Þehir Hastanesi Genel Cerrahi Servisi,Ankara
⁴Ankara Þehir Hastanesi Biyokimya Kiliniði,Ankara

GÝRÝÞ ve AMAÇ: Bu çalýþmanýn amacý acil servise karbon monoksit zehirlenmesi nedeniyle baþvuran hastalarda oksidatif stres markerlarýndan olan thiol/disülfit homeostazis parametreleri ile Nötrofil-Lenfosit (NLO) beraber kullanýmýnýn taný açýsýndan yararlý olup olmadýðýný araþtýrmaktýr.
YÖNTEM ve GEREÇLER: Çalýþma 01.01.2014 ile 01.03.2015 tarihleri arasýnda acil servise baþvuran ve çalýþmaya alýnan 45 hasta ve kontrol grubu olarak belirlenen 40 saðlýklý kiþi ile prospektif olarak yapýldý. Erel ve Neþelioðlu tarafýndan yeni geliþtirilen bir metot ile oksidatif stres markerý olan thiol/disülfit homeostazis parametreleri (Thiol, disülfit, disülfit/native thiol, disülfit/total thiol, native thiol/total thiol) ile NLO hasta ve kontrol grubunda çalýþýldý.
BULGULAR: Karbonmonoksit zehirlenmesi olanlarda kontrol grubuna göre, NT, TT, index 3 ve NLO oranlarýnda anlamlý farklýlýk tespit edildi. NT, TT ve index 3 hasta grubunda daha düþük, NLO ortalama deðerleri daha yüksek bulundu (sýrasýyla p =0,005; < 0,001; < 0,032 ve < 0,001).
TARTIÞMA ve SONUÇ: NLO ile thiol/disülfit homeostasis parametrelerinin karbonmonoksit zehirlenmesi tanýsýnda beraber kullanýlmasý bu hastalarda tanýnýn konulmasý açýsýndan faydalýdýr.

Anahtar Kelimeler: Karbonmonoksit zehirlenmesi, NLO, thiol/disulphide homeostasis

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