Ankara Med J. 2020; 20(3): 730-742 | DOI: 10.5505/amj.2020.59254

Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss

Sabri Colak¹, Emine Seda Guvendag Guven², Suleyman Guven², Turan Erdogan³, Yeþim Bayoglu Tekin⁴, Funda Akpýnar^5
1Department of Obstetrics and Gynecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
²Department of Gynecology and Obstetrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
³Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey
⁴Department of Gynecology and Obstetrics, Saðlýk Bilimleri University, School of Medicine, Ýstanbul, Turkey
⁵Department of Gynecology and Obstetrics, University of Health Sciences, Ankara Etlik Zübeyde Haným Training and Research Hospital, Ankara, Turkey

INTRODUCTION: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL).
METHODS: This prospective and single-center study included 20-40-year-old 30 patients with and 30 patients without a history of RPL. No patients with any anatomical, hereditary, or endocrinological thrombophilic defects were included. Comparison of SCUBE-1 levels and CIMT were made between the patient and control groups.
RESULTS: There were no statistically significant differences between patients and control groups in terms of demographic characteristics except for gravidity, parity and miscarriages.The mean SCUBE-1 level in the RPL group was statistically significantly higher compared to the control group (16.44±5.43 vs.10.17±5.19, respectively, p=0.001). The mean CIMT value in RPL patients was statistically significantly higher than that of the control group (0.60±0.09 vs.0.44±0.07, respectively, p=0.001).
DISCUSSION AND CONCLUSION: High levels of serum SCUBE-1 and CIMT in RPL may suggest that ischemia and endothelial dysfunction may be involved in the etiology of RPL. Future studies may shed light on the diagnosis, treatment, and management of RPL.

Keywords: Abortion, Habitual, SCUBE1 protein, Carotid Intima-Media Thickness

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Tekrarlayan Gebelik Kayýplarýnda SCUBE-1 Düzeyinin ve Karotis Ýntima Media Kalýnlýðýnýn Deðerlendirilmesi

Sabri Colak¹, Emine Seda Guvendag Guven², Suleyman Guven², Turan Erdogan³, Yeþim Bayoglu Tekin⁴, Funda Akpýnar^5
1Recep Tayyip Erdoðan Üniversitesi Týp Fakültesi, Kadýn Hastalýklarý ve Doðum Ana Bilim Dalý, Rize
²Karadeniz Teknik Üniversitesi Týp Fakültesi, Kadýn Hastalýklarý ve Doðum Ana Bilim Dalý, Trabzon
³Recep Tayyip Erdoðan Üniversitesi Týp Fakültesi, Kardiyoloji Ana Bilim Dalý, Rize
⁴Saðlýk Bilimleri Üniversitesi Týp Fakültesi Kadýn Hastalýklarý ve Doðum Ana Bilim Dalý, Ýstanbul
⁵Saðlýk Bilimleri Üniversitesi Týp Fakültesi Kadýn Hastalýklarý ve Doðum Ana Bilim Dalý, Ankara Etlik Zübeyde Haným Eðitim ve Araþtýrma Hastanesi, Ankara

GÝRÝÞ ve AMAÇ: Tekrarlayan gebelik kaybý olan hasta grubu ile tekrarlayan gebelik kaybý öyküsü olmayan hasta grubu arasýnda serum signal peptid C1r/C1s, Uegf, ve Bmp1 (CUB) epidermal growth factor-like domain-containing protein-1 (SCUBE-1) düzeyinin ve karotis intima media kalýnlýðýnýn deðerlendirilmesi
YÖNTEM ve GEREÇLER: Prospektif ve tek merkezli çalýþmaya 20-40 yaþ arasýnda 30 tekrarlayan gebelik kaybý öyküsü olan, 30 tekrarlayan gebelik kaybý öyküsü olmayan hasta olgusu alýnmýþtýr. Tekrarlayan gebelik kaybý olanlarda ve kontrol grubunda anatomik, kalýtýmsal, endokrin, trombofilik defekti olanlar çalýþma kapsamýna alýnmamýþtýr.Hasta grubu ile kontrol grubu arasýnda SCUBE-1 düzeyinde ve ölçülen karotis intima media kalýnlýðý arasýnda istatistiksel fark olup olmadýðý araþtýrýlmýþtýr.
BULGULAR: Demografik özellikler açýsýndan hastalar ve kontrol gruplarý arasýnda gravite, parite ve düþükler dýþýnda istatistiksel olarak anlamlý fark bulunmamýþtýr.Tekrarlayan gebelik kaybý olan hastalarýn ortalama SCUBE1 düzeyleri (16,44±5,43) kontrol grubunun ortalama SCUBE1 düzeylerinden (10,17±5,19) istatistiksel olarak anlamlý þekilde yüksektir (p=0,001). TGK kaybý olan hastalarýn ortalama CIMT düzeyleri (0,60±0,09) kontrol grubunun ortalama CIMT düzeylerinden (0,44±0,07) istatistiksel olarak anlamlý þekilde yüksektir (p=0,001).
TARTIÞMA ve SONUÇ: TGK olan grupta yüksek serum SCUBE-1 ve CIMT seviyeleri, iskemi ve endotel disfonksiyonunun TGK etiyolojisinde rol oynayabileceðini düþündürebilir. Gelecekteki çalýþmalar TGK'nýn taný, tedavi ve yönetimine ýþýk tutabilir.

Anahtar Kelimeler: Düþük, tekrarlayan, SCUBE1 protein, Karotis iç-orta kalýnlýðý

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