E-ISSN: 2148-4570 • ISSN:2148-4570
Are Pituitary Functions Different in Obese Patients According to Body Mass Index Classes? [Ankara Med J]
Ankara Med J. 2023; 23(2): 201-209 | DOI: 10.5505/amj.2023.26096

Are Pituitary Functions Different in Obese Patients According to Body Mass Index Classes?

Neslihan Çuhacı Seyrek
Department of Endocrinology and Metabolism, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey

INTRODUCTION: In this study, we aimed to evaluate whether there is a difference in the pituitary functions in obese patients according to the different body mass index (BMI) classes
METHODS: We retrospectively evaluated 192 patients with obesity. According to the obesity degree, patients were divided into class I (BMI;30.0-34.9 kg/m2), class II (BMI; 35.0-39.9 kg/m2) or class III (BMI; ≥40 kg/m2) obesity. The demographic data of the patients (sex, age), thyroid function tests, estrogen (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), insulin-like growth factor-I (IGF-I), total and free testosterone, cortisol, adrenocorticotrophic hormone (ACTH) levels were measured. Also, 24-hour urine-free cortisol levels and a 1 mg dexamethasone suppression test were performed.
RESULTS: Total of the 192 patients, 44 (22.92%) were male, 148 (77.08%) were female. According to BMI classes, 12 (6.25%) patients were in class I, 38 (19.79%) patients were in class II and 142 (73.96%) patients were in class III obesity. No significant difference was found between the groups in hormonal parameters except the IGF-I level. 1 mg dexamethasone suppression test was suppressed in all patients.
DISCUSSION AND CONCLUSION: In our study, we found that there was no difference in pituitary functions according to obesity classes, except for the IGF-I level. Further studies are needed to investigate these functions in different classes of obesity.

Keywords: Obesity, body mass index, pituitary functions, insulin-like growth factor-I.

Neslihan Çuhacı Seyrek. Are Pituitary Functions Different in Obese Patients According to Body Mass Index Classes?. Ankara Med J. 2023; 23(2): 201-209

Corresponding Author: Neslihan Çuhacı Seyrek, Türkiye
Manuscript Language: English
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